“The Great Hurricane of 1780, also known as Hurricane San Calixto, the Great Hurricane of the Antilles, and the 1780 Disaster is the deadliest Atlantic hurricane on record.
“Over 20,000 people died when the storm passed through the Lesser Antilles in the Caribbean between October 10 and October 16. Specifics on the hurricane’s track and strength are unknown since the official Atlantic hurricane database only goes back to 1851.”
This was long before carbon dioxide from fossil fuels began to accumulate in the atmosphere. Hurricane Katrina, et al, have been pikers by comparison.